Protesters were seen throwing objects at police in the EU country’s capital. Officers were seen trying to disperse stone-throwing youths after an anti-lockdown protest turned violent.
During the day around 3,500 protestors marched from the Gare du Nord railway to a park in the city’s European quarter.
It later turned violent when a small group of hooded protesters clashed with riot officers protecting the route to EU headquarters, where officials were meeting African leaders.
It comes as Belgium recorded around 10,000 new Covid cases per day as the Omicron variant spreads in Europe.
The protests came as Prime Minister Alexander De Croo’s Government prepares to meet on Wednesday to decide on any new measures to try and combat the spread of Omicron.
Ahead of Wednesday’s meeting, the Belgium Government has strongly advised all residents to get vaccinated.
It has given health care workers a three-month window to get vaccinated against the virus beginning January 1 or risk losing their jobs.
At a protest in Brussels earlier this month, police used water cannon and teargas to disperse protesters who were opposed to compulsory health measures against the coronavirus pandemic.
About 8,000 people marched through Brussels towards the headquarters of the EU, chanting “freedom” and letting off fireworks.
The crowd was smaller than the 35,000 vaccine and lockdown sceptics who marched last month, and police were better prepared.
December’s protests came shortly after violence erupted as tens of thousands of protesters took to the streets of Brussels last month.
The march, which police estimated involved 35,000 people, began peacefully but descended into violence as several hundred people started pelting officers, smashing cars and setting rubbish bins on fire. Police responded with teargas and water cannon.